Proton Translocation In Proteins

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Proton translocation in proteins.

The active transport of protons across the low dielectric barrier imposed by biological membranes is accomplished by a plethora of proteins that span the ca. 40 ~ of the phospholipid bilayer. The free energy derived from the proton electrochemical potential established by the translocation of these protons can subsequently be used to drive vital chemical reactions of the cell, such as ATP synth...

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Evidence has been gathering from several laboratories that protons in proton-pumping membranes move along or within the bilayer rather than exchange with the bulk phase. These experiments are typically conducted on the natural membrane in vivo or in vitro or on fragments of natural membrane. Anionic lipids are present in all proton-pumping membranes. Model studies on the protonation state of th...

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ژورنال

عنوان ژورنال: Annual Review of Physical Chemistry

سال: 1989

ISSN: 0066-426X

DOI: 10.1146/annurev.physchem.40.1.671